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KMID : 0616120120430030239
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 3 p.239 ~ p.242
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In vitro Anti-malarial Activity of Juniperus Chinensis Extract
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Lee Keyong-Ho
Kim Byung-Soo
Choe Yeong-Ho
Rhee Ki-Hyeong
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Abstract
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This study was carried out to investigate the anti-malarial activity of Juniperus chinensis by in vitro and in vivo system using Plasmodium falciparum chloroquine-sensitive(3D7) and P. falciparum chloroquine-resistant(S20) strains. According to cytotoxicty test on NIH 3T3 cell, the ethanol extract(EtOH), ethylacetate(EtOAc) fraction and aqueous fraction possessed significant anti-malarial activity against both 3D7 and S20 strains at non-toxic concentrations(<100 /). In vitro assay, EtOAc fraction showed notable activity against 3D7 and S20 strains of P. falciparum with values of and . In animal test using P. falciparum infected human erythrocytes, the treatment of EtOAc fraction significantly inhibited parasitaemia in mice in a dose-dependent manner that is parasitaemia of 42%, 34% and 31% in doses of 10 mg/kg, 20 mg/kg and 40 mg/kg, respectively. The study provides data to support the medicinal importance of the J. chinensis.
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KEYWORD
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Juniperus chinensis, Malaria, Plasmodium falciparum
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